I don’t regard most of moviedom’s stand-out female villains as odious or reprehensible. Because most of those that come to mind are cartoonish — broadly drawn, lacking any semblance of realism or subtlety…fiendish stereotypes, outlandish behavior, etc.

Glenn Close‘s Cruella DeVille, Margaret Hamilton‘s Wicked With of the West, Angelina Jolie‘s Maleficent are histrionic, flamboyantly written comic-book figures…satirical cliches, basically created for children.

In Get Out, I didn’t believe Alison Williams‘ evil racist girlfriend for one single millisecond. Kathy Bates‘ “Annie Wilkes” from Misery (’90) is another over-the-top fanatic. Even Louise Fletcher‘s Nurse Ratched isn’t “real” — she’s more of a personification of a drab and repressive system that stifles the human spirit.

If you eliminate the third-act murder of Neil Patrick Harris, Rosamund Pike‘s “Amy Dune” from Gone Girl is slightly more real-worldish; ditto Close’s Alex Forrest from Fatal Attraction, although Alex isn’t demonic as much as tragically demented.

Honestly? When you tabulate all the thousands of films I’ve seen, the female character I’ve despised the most in terms of actual life-resembling behavior is Diane Venora‘s “Liane” Wigand, the spineless wife of Russell Crowe‘s Jeffrey Wigand in Michael Mann‘s The Insider.

The 1999 drama depicts Liane as a shallow, insulated security queen who leaves the embattled Wigand, taking their kids with her, when the going gets too tough.

Sidenote: Liane is a fictional creation — 23 years ago the ex-wife of the actual whistleblower, named Lucretia Nimocks, told N.Y. Post journalist Jeane MacIntosh “that’s not the way it happened at all.”

Liane is at the top of my list because I regard cowardice and disloyalty as the most abhorrent human qualities on the planet earth.