Women commonly say “you know what?” before declaring they’ve had it with you because you’ve crossed some kind of rhetorical or behavioral line. They’ll say it before deciding to terminate a conversation or a relationship or whatever. “You know what? We’re finished talking” or “You know what? I don’t think this is going to work out”…that line of country. I recall producer Stacy Sher saying this to me in the mid or late ’90s when I got a little too pushy during a phone interview. I’m mentioning this phrase because I’ve never once heard a guy, straight or gay, say “you know what?” This is strictly a female expression. There are very few that are exclusive to one gender or another, but “you know what?” is apparently one of them. Unless someone has different information.